Publications of the Week Patient-Reported Outcomes Following Abiraterone Acetate Plus Prednisone Added to Androgen Deprivation Therapy in Patients With Newly Diagnosed Metastatic Castration-Naive Prostate Cancer (LATITUDE): An International, Randomised Phase 3 TrialChi, K.N., and Fizazi, K., et al. | February 1, 2018In the LATITUDE trial, addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT)…sciencecityFebruary 1, 2018 Read More
Publications of the Week Good Bug, Bad Bug: Breaking Through Microbial StereotypesCirstea, M. and Finlay, B.B., et al. | January 29, 2018Our expanding knowledge of microbial mechanisms is challenging the notion of “good” versus “bad” microbes…sciencecityJanuary 29, 2018 Read More
Publications of the Week Hypoxia Induces Selective Modifications to the Acetylome in the Brain of Zebrafish (Danio rerio)Dhillon, R.S. and Richards, J.G. | January 26, 2018Reversible protein acetylation is an important regulatory mechanism for modulating protein function. The cellular protein…sciencecityJanuary 26, 2018 Read More
Publications of the Week Integration of Biological/Pathophysiological Contexts to Help Clarify Genotype-Phenotype Mismatches in Monogenetic Diseases. Childhood Epilepsies Associated with SCN2A as a Case StudyWinquist, R.J. and Cohen, C.J. | January 24, 2018Monogenetic diseases offer clear human validation for launching drug discovery programs in Pharma designed to…sciencecityJanuary 24, 2018 Read More
Publications of the Week Hyaluronan-Binding by CD44 Reduces the Memory Potential of Activated Murine CD8 T CellsLee-Sayer, S.S.M. and Johnson, P., et al. | January 22, 2018In this paper, we found that CD44 and its interaction with its ligand, the extracellular…sciencecityJanuary 22, 2018 Read More
Publications of the Week ChopStitch: Exon Annotation and Splice Graph Construction Using Transcriptome Assembly and Whole Genome Sequencing DataKhan, H. and Birol, I., et al. | January 19, 2018Read the Publication This week we profile a recent publication in Bioinformatics from Dr. Inanc…sciencecityJanuary 19, 2018 Read More
Publications of the Week REVIEW: Translational Control of Aberrant Stress Responses as a Novel Hallmark of CancerEl-Naggar, A.M. and Sorensen, P.H. | January 18, 2018Altered mRNA translational control is emerging as a critical factor in cancer development and progression.…sciencecityJanuary 18, 2018 Read More
Publications of the Week A Library-Based Screening Method Identifies Neoantigen-Reactive T Cells in Peripheral Blood Prior to Relapse of Ovarian CancerMartin, S.D. and Nelson, B.H., et al. | January 16, 2018Mutated cancer antigens, or neoantigens, represent compelling immunological targets and appear to underlie the success…sciencecityJanuary 16, 2018 Read More
Publications of the Week Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine CellsSabatini, P.V. and Lynn, F.C., et al. | January 15, 2018Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene…sciencecityJanuary 15, 2018 Read More
Publications of the Week Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive FunctionConnor, S.A. and Craig, A.M., et al. | January 12, 2018Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic…sciencecityJanuary 12, 2018 Read More