Publications of the Week BLM Helicase Suppresses Recombination at G-Quadruplex Motifs in Transcribed Genes Van Wietmarschen, N. and Lansdorp, P.M., et al. | February 5, 2018 My lab is exploring various applications of our single cell DNA template strand sequencing technique…sciencecityFebruary 5, 2018 Read More
Publications of the Week Cognitive Planning Neural Correlates in a Pediatric Monozygotic Twin Pair Discordant for Obsessive-Compulsive Disorder: Exploring Potential Application in Precision Medicine Jaspers-Fayer, F. and Stewart, S.E., et al. | February 2, 2018 Pediatric obsessive-compulsive disorder (OCD) is a debilitating illness characterized by intrusive thoughts and repetitive behaviors.…sciencecityFebruary 2, 2018 Read More
Publications of the Week Patient-Reported Outcomes Following Abiraterone Acetate Plus Prednisone Added to Androgen Deprivation Therapy in Patients With Newly Diagnosed Metastatic Castration-Naive Prostate Cancer (LATITUDE): An International, Randomised Phase 3 Trial Chi, K.N., and Fizazi, K., et al. | February 1, 2018 In the LATITUDE trial, addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT)…sciencecityFebruary 1, 2018 Read More
Publications of the Week Good Bug, Bad Bug: Breaking Through Microbial Stereotypes Cirstea, M. and Finlay, B.B., et al. | January 29, 2018 Our expanding knowledge of microbial mechanisms is challenging the notion of “good” versus “bad” microbes…sciencecityJanuary 29, 2018 Read More
Publications of the Week Hypoxia Induces Selective Modifications to the Acetylome in the Brain of Zebrafish (Danio rerio) Dhillon, R.S. and Richards, J.G. | January 26, 2018 Reversible protein acetylation is an important regulatory mechanism for modulating protein function. The cellular protein…sciencecityJanuary 26, 2018 Read More
Publications of the Week Integration of Biological/Pathophysiological Contexts to Help Clarify Genotype-Phenotype Mismatches in Monogenetic Diseases. Childhood Epilepsies Associated with SCN2A as a Case Study Winquist, R.J. and Cohen, C.J. | January 24, 2018 Monogenetic diseases offer clear human validation for launching drug discovery programs in Pharma designed to…sciencecityJanuary 24, 2018 Read More
Publications of the Week Hyaluronan-Binding by CD44 Reduces the Memory Potential of Activated Murine CD8 T Cells Lee-Sayer, S.S.M. and Johnson, P., et al. | January 22, 2018 In this paper, we found that CD44 and its interaction with its ligand, the extracellular…sciencecityJanuary 22, 2018 Read More
Publications of the Week ChopStitch: Exon Annotation and Splice Graph Construction Using Transcriptome Assembly and Whole Genome Sequencing Data Khan, H. and Birol, I., et al. | January 19, 2018 Read the Publication This week we profile a recent publication in Bioinformatics from Dr. Inanc…sciencecityJanuary 19, 2018 Read More
Publications of the Week REVIEW: Translational Control of Aberrant Stress Responses as a Novel Hallmark of Cancer El-Naggar, A.M. and Sorensen, P.H. | January 18, 2018 Altered mRNA translational control is emerging as a critical factor in cancer development and progression.…sciencecityJanuary 18, 2018 Read More
Publications of the Week A Library-Based Screening Method Identifies Neoantigen-Reactive T Cells in Peripheral Blood Prior to Relapse of Ovarian Cancer Martin, S.D. and Nelson, B.H., et al. | January 16, 2018 Mutated cancer antigens, or neoantigens, represent compelling immunological targets and appear to underlie the success…sciencecityJanuary 16, 2018 Read More